Mercedes-Benz S250 CDI/Mercedes-Benz S300/Mercedes-Benz S320 CDI/Mercedes-Benz S350/Mercedes-Benz S350 Bluetec/Mercedes-Benz S350 CDI/Mercedes-Benz S400/Mercedes-Benz S450/Mercedes-Benz S500/Mercedes-Benz S550/Mercedes-Benz S63 AMG/Mercedes-Benz S600/Mercedes-Benz S65 AMG (W221). 2005–13 (prod. n/a). 4-door saloon, 4-door LWB saloon. F/R, F/A, 2143 cm³ diesel (I4 DOHC), 2996, 3498 cm³ petrol, 3498 cm³ petrol–electric hybrid, 2987 cm³ diesel (V6 DOHC), 4663, 5461, 6208 cm³ (V8 DOHC), 5513, 5980 cm³ (V12 OHC). Larger replacement for W220, and Mercedes-Benz’s technological tour de force. Doors that stay open regardless of angle, night vision, accident prevention system, and high-resolution digital dashboard among the features; massaging and air-supported seats among the options. More powerful engines. Better reliability after criticisms over W220. Fussier styling, with character lines over wheel arches.

Manufacturing location: Sindelfingen, Germany

Marque: Mercedes-Benz | Model: Mercedes-Benz S-Klasse | Predecessor: Mercedes-Benz S-Klasse (W220) | Successor: Mercedes-Benz S-Klasse (W222)

q.v. Mercedes-Benz CL (C216)